IEEE ICES Database
ElectroMagnetic Field Literature
Search Engine
IEEE ICES website
  

EMF Study
(Database last updated on Mar 1, 2021)

ID Number 426
Study Type In Vivo
Model 2450 MHz (CW, PW) exposure to mice and analysis of tumor progression (B16 melanoma cell line injection bioassay)
Details

C57BL/6J mice (5 wk old females) were injected with B16 melanoma cells (3 x 10(6)) and exposed to 2450 MHz (CW & PW as 10 usec pulses for 10 msec repeated at 25 Hz) RF at an SAR of 1.2 W/kg (whole body average). Exposures were for 2.5 hr/day, 6 days/wk for 15 days prior to tumor cell injection, followed by exposure on the same schedule until death at ~26 days. No significant effects were observed on mean tumor surface area or survival times with RF exposure (mean = 25 days). In a related microwave study (J Microw Power (1986) 21(1):41-44), B16 melanoma cells were exposed to 2450 MHz (CW) at a power density of 40 mW/cm2 (producing a temperature of 44 C) for 20 minutes and injected into mice to induce an immune response. Animals immunized with hyperthermia-exposed B16 cells survived significantly longer upon subsequent injection with viable B16 melanoma cells. The authors speculate that microwave hyperthermia may facilitate chemical and/or conformational changes in various antigenic molecules on B16 cells favoring a good immune response.

Findings No Effects
Status Completed With Publication
Principal Investigator Lab Physiology & Pharmacodynamics, INSA, France - rsantini@insa.insa-lyon.fr
Funding Agency Private/Instit.
Country FRANCE
References
  • Santini, R et al. Bioelectromagnetics, (1988) 9:105-107
  • Comments

    Return