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EMF Study
(Database last updated on Sep 28, 2022)

ID Number 2125
Study Type In Vivo
Model 50 Hz (ELF) and 900 MHz exposure to rats and analysis of memory and behavior.

Young rats were exposed to 50 Hz (ELF) in combination with iron treatment. The authors report iron overload alone did decrease detection of a spatial change in an object exploration task and decreased seretonin levels. Co-exposure with ELF did not potentiate these effects on spatial learning and memory, nor did it have any effect on performance in a reference (Morris water maze) or a working memory task (8-arm radial maze). AUTHORS' ABSTRACT: Maaroufi et al. 2014 (IEEE #6248): The increasing use of mobile phone technology over the last decade raises concerns about the impact of high frequency electromagnetic fields (EMF) on health. More recently, a link between EMF, iron overload in the brain and neurodegenerative disorders including Parkinson's and Alzheimer's diseases has been suggested. Co-exposure to EMF and brain iron overload may have a greater impact on brain tissues and cognitive processes than each treatment by itself. To examine this hypothesis, Long-Evans rats submitted to 900 MHz exposure or combined 900 MHz EMF and iron overload treatments were tested in various spatial learning tasks (navigation task in the Morris water maze, working memory task in the radial-arm maze, and object exploration task involving spatial and non spatial processing). Biogenic monoamines and metabolites (dopamine, serotonin) and oxidative stress were measured. Rats exposed to EMF were impaired in the object exploration task but not in the navigation and working memory tasks. They also showed alterations of monoamine content in several brain areas but mainly in the hippocampus. Rats that received combined treatment did not show greater behavioral and neurochemical deficits than EMF-exposed rats. None of the two treatments produced global oxidative stress. These results show that there is an impact of EMF on the brain and cognitive processes but this impact is revealed only in a task exploiting spontaneous exploratory activity. In contrast, there are no synergistic effects between EMF and a high content of iron in the brain.

Findings No Effects
Status Completed With Publication
Principal Investigator Aix-Marseille Université CNRS, France
Funding Agency Private/Instit.
Country FRANCE
  • Maaroufi, K et al. Neurobiol Learn Mem, (2009) 92:345-355
  • Maaroufi, K et al. Behav Brain Res., (2014) 258:80-89
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